RESUMO
A series of 119 patients with 122 gastric carcinomas treated by gastrectomy, with a follow up of more than 5 years is presented. There were 80 (67.2%) men and 39 (32.8%) women with a mean age of 66.4 years. In 101 (84.9%) the diagnosis of cancer was endoscopic. Pain was the most frequent symptom (55.5%). Seventy two (59%) were localized in the antrum; 26 (21%) were cardial, and 24 (19.7%) were in the body. In 43.4% the size was smaller than 5 cm and in 56.6% it measured 5 cm or more. Eighty nine (73%) were of the intestinal type, 15 (12.3%) were diffuse and 18 (14.8%) were mixed. Eighty (65.6%) were low histological grade and 42 (34.4%) were high grade. Ten (9.2%) were early carcinomas and 112 (91.8%) advanced carcinomas. An amplification of the c-erbB-2 oncogene was associated with tumors that were smaller than 5 cm (p = 0.05) and with histological low grade (p = 0.005). A five years survival correlated with tumors smaller than 5 cm (p = 0.02), with parietal infiltration not surpassing the muscular layer (p = 0.001), and without lymph node metastases (p = 0.001). There was no association between survival and amplification of c-erbB-2 oncogene.
Assuntos
Neoplasias Gástricas/patologia , Idoso , Feminino , Seguimentos , Amplificação de Genes , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Proto-Oncogenes , Neoplasias Gástricas/genética , Neoplasias Gástricas/mortalidadeRESUMO
A series of 119 patients with 122 gastric carcinomas treated by gastrectomy, with a follow up of more than 5 years is presented. There were 80 (67.2
) men and 39 (32.8
) women with a mean age of 66.4 years. In 101 (84.9
) the diagnosis of cancer was endoscopic. Pain was the most frequent symptom (55.5
). Seventy two (59
) were localized in the antrum; 26 (21
) were cardial, and 24 (19.7
) were in the body. In 43.4
the size was smaller than 5 cm and in 56.6
it measured 5 cm or more. Eighty nine (73
) were of the intestinal type, 15 (12.3
) were diffuse and 18 (14.8
) were mixed. Eighty (65.6
) were low histological grade and 42 (34.4
) were high grade. Ten (9.2
) were early carcinomas and 112 (91.8
) advanced carcinomas. An amplification of the c-erbB-2 oncogene was associated with tumors that were smaller than 5 cm (p = 0.05) and with histological low grade (p = 0.005). A five years survival correlated with tumors smaller than 5 cm (p = 0.02), with parietal infiltration not surpassing the muscular layer (p = 0.001), and without lymph node metastases (p = 0.001). There was no association between survival and amplification of c-erbB-2 oncogene.
